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Article

Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine

30 Oct 2023

Abstract excerpt

To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines, encoding both ancestral and Omicron BA.5 spikes, have replaced monovalent vaccines in numerous countries. However, fourth doses of either vaccine result in similar neutralizing antibody titers against Omicron subvariants, raising the possibility of immunological imprinting. To address this, we investigate antibody responses in 72...

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PMID: 37909042
DOI: 10.1016/j.xcrm.2023.101258

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