Article

Reduced antigenicity of Omicron lowers host serologic response

2022-02-15

Abstract excerpt

SARS-CoV-2 Omicron variant of concern (VOC) contains fifteen mutations on the receptor binding domain (RBD), evading most neutralizing antibodies from vaccinated sera. Emerging evidence suggests that Omicron breakthrough cases are associated with substantially lower antibody titers than other VOC cases. However, the mechanism remains unclear. Here, using a novel geometric deep-learning model, we discovered that th...

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Literature Corpus work: ed53358b-2e1c-582d-a339-e3f779f0a783
DOI: 10.1101/2022.02.15.480546

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