Article

An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

2023-03-15

Abstract excerpt

The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyzed blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyzed their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both ance...

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Literature Corpus work: d126f2b7-7307-5eb8-8778-c86a3ac88e42
DOI: 10.1101/2023.03.15.532728

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