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An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

20 Apr 2024

Abstract excerpt

The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyze their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both...

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PMID: 38643233
DOI: 10.1038/s41467-024-47743-1

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