Article

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Given the critical role of CD4 T cells in anti-tumor immunity, strategies to harness these cells for cancer immunotherapy are gaining increasing interest. Historically overshadowed by CD8 T cells, cytotoxic CD4 T cells can directly kill MHC class II-expressing tumor cells. However, the defining molecular signature and the mechanisms underlying their cytolytic activity remain poorly understood, p...

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Literature Corpus work: 397c2b0f-0daf-5016-8955-b26f85488e94
DOI: 10.64898/2026.04.13.718113

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