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Article

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

Blood - 1 Sept 2000

Williams D A, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine J E, Petryniak B, Derrow C W, Harris C, Jia B, Zheng Y, Ambruso D R, Lowe J B, Atkinson S J, Dinauer M C, Boxer L

Abstract excerpt

Rho GTPases control a variety of cellular processes, including actin polymerization, integrin complex formation, cell adhesion, gene transcription, cell cycle progression, and cell proliferation. A patient is described who has recurrent infections and defective neutrophil cellular functions similar to those found in Rac2-deficient mice. Molecular methods were used to clone the expressed Rac2 cDNA from this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10961859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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