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Article

Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2005

Carstanjen Dirk, Yamauchi Akira, Koornneef Annemart, Zang Heesuk, Filippi Marie-Dominique, Harris Chad, Towe Jason, Atkinson Simon, Zheng Yi, Dinauer Mary C, Williams David A

Abstract excerpt

Polymorphonuclear neutrophils (PMN) are an important component of the innate immune system. We have shown previously that migration and superoxide (O2*-) production, as well as some kinase signaling pathways are compromised in mice deficient in the Ras-related Rho GTPase Rac2. In this study, we demonstrate that Rac2 controls chemotaxis and superoxide production via distinct pathways and is critical for...

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Share to Chemotaxis, Leukocyte
Share to Colony-Forming Units Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p21-Activated Kinases

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Share to rho-Associated Kinases

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Source

Identifiers

PMID: 15814684
DOI: 10.4049/jimmunol.174.8.4613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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