Article

Clemizole and Trazodone are Effective Antiseizure Treatments in a Zebrafish Model of STXBP1 Disorder

2022-01-30

Abstract excerpt

<h4>Objective</h4> CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b , a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient preclinical platform to test antiseizure therapeutics. The present study was designed to test prototype antiepileptic drugs a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6011662-c014-5215-9c7b-b9fcc0939cc1
DOI: 10.1101/2022.01.30.478390

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clemizole and Trazodone are Effective Antiseizure Treatments in a Zebrafish Model of STXBP1 DisorderDOI 10.1101/2022.01.30.478390Read

Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish modelSemantic proximity Read

Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish modelSemantic proximity Read

Drug repurposing for Dravet syndrome in scn1Lab−/− mutant zebrafishSemantic proximity Read

Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndromeSemantic proximity Read

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model.Semantic proximity Read

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish ModelSemantic proximity Read

Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish ProjectSemantic proximity Read

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndromeSemantic proximity Read

A large-scale mutagenesis screen to identify seizure-resistant zebrafish.Semantic proximity Read

Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS contract site for the Epilepsy Therapy Screening ProgramSemantic proximity Read

A de novo nonsense mutation of STXBP1 causes early-onset epileptic encephalopathy.Semantic proximity Read

Toward the use of novel alternative methods in epilepsy modeling and drug discoverySemantic proximity Read