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LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

13 Jul 2023

Abstract excerpt

Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, some tumors undergo cellular reprogramming to a more lethal subset termed neuroendocrine prostate cancer (NEPC) with neuronal differentiation. The frequency of NEPC is increasing since the...

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PMID: 37440313
DOI: 10.1172/jci.insight.167440

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