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Article

Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation.

Scientific reports - 4 Aug 2017

Pongor Lőrinc, Harami-Papp Hajnalka, Méhes Előd, Czirók András, Győrffy Balázs

Abstract excerpt

Short and long distance cell dispersal can have a marked effect on tumor structure, high cellular motility could lead to faster cell mixing and lower observable intratumor heterogeneity. Here we evaluated a model for cell mixing that investigates how short-range dispersal and cell turnover will account for mutational proportions. We show that cancer cells can penetrate neighboring and distinct areas in a matter...

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Identifiers

PMID: 28779157
DOI: 10.1038/s41598-017-07487-z
PMCID: PMC5544774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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