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Article

Population genetic simulations of complex phenotypes with implications for rare variant association tests.

Genetic epidemiology - 1 Jan 2015

Uricchio Lawrence H, Torres Raul, Witte John S, Hernandez Ryan D

Abstract excerpt

Demographic events and natural selection alter patterns of genetic variation within populations and may play a substantial role in shaping the genetic architecture of complex phenotypes and disease. However, the joint impact of these basic evolutionary forces is often ignored in the assessment of statistical tests of association. Here, we provide a simulation-based framework for generating DNA sequences that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25417809
DOI: 10.1002/gepi.21866
PMCID: PMC4270825

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