Article

Modeling Endothelial Dysfunction in IPF: Bridging Mechanistic Insights and Translational Applications

2025-12-22

Abstract excerpt

<title>Abstract</title> <p> Background Gas exchange in the alveolus, the lung’s primary unit, relies on coordinated interactions between epithelial and endothelial layers. In idiopathic pulmonary fibrosis (IPF), the structural and functional integrity of this alveolar unit is profoundly disrupted, leading to impaired respiratory capacity. Although epithelial and mesenchymal compartments have been extensively st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a8bbc68-f499-53db-81d7-c15416093a48
DOI: 10.21203/rs.3.rs-8256899/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Endothelial Dysfunction in IPF: Bridging Mechanistic Insights and Translational ApplicationsDOI 10.21203/rs.3.rs-8256899/v1Read

Modeling Endothelial Dysfunction in Idiopathic Pulmonary Fibrosis: Bridging Mechanistic Insights and Translational ApplicationsSemantic proximity Read

ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosisSemantic proximity Read

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension.Semantic proximity Read

Endothelial Heterogeneity in Pulmonary Hypertension.Semantic proximity Read

Lung endothelial cell heterogeneity in health and pulmonary vascular diseaseSemantic proximity Read

Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertensionSemantic proximity Read

Characterization of the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis using single-cell RNA sequencingSemantic proximity Read

A vascularized human lung-on-a-chip reveals compartmentalized inflammatory responses in bacterial pneumoniaSemantic proximity Read

Organ on chip model of respiratory vascular interactions under COPD relevant oxidative stressSemantic proximity Read

Integrated Single Cell Atlas of Endothelial Cells of the Human LungSemantic proximity Read

Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary FibrosisSemantic proximity Read

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial HypertensionSemantic proximity Read