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Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

9 Sept 2021

Abstract excerpt

AIMS: Endothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell resolution. METHODS AND RESULTS: We carried out single-cell RNA sequencing (scRNA-seq) of lung ECs isolated from an EC lineage-tracing mouse model in Control and SU5416/hypoxia-induced PAH conditions. EC populations corresponding to...

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Angiogenesis and VEGF in Cancer
Pulmonary Hypertension Research and Treatments
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34528097
DOI: 10.1093/cvr/cvab296

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