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Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis

3 Sept 2025

Abstract excerpt

Introduction: Silicosis is a progressive fibrotic lung disease without effective treatment options, and its pathogenesis remains incompletely understood, particularly the role of endothelial cells (ECs). Methods: Here, we utilized single-cell RNA sequencing to characterize endothelial responses in lungs from silica-exposed mice. Results: We identified two functionally distinct endothelial subpopulations: 1. An...

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PMID: 40969743
DOI: 10.3389/fimmu.2025.1629226

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