Article
Endothelial Heterogeneity in Pulmonary Hypertension.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2026
Zhao Hanqiu, Chakinala Murali M, Fallon Michael B, Lin Susan M, Lee Janet S, Dai Zhiyu
Abstract excerpt
The lung endothelium is essential for maintaining normal lung structure and plays a key role in gas exchange, barrier function, angiogenesis, vascular tone, and inflammation regulation. The advent of single-cell RNA sequencing has revealed the unique heterogeneity of pulmonary endothelial cells (ECs) in their function, morphology, and localization. Pulmonary hypertension (PH) is a progressive vascular disorder...
Topics
- Humans
- Hypertension, Pulmonary
- Endothelial Cells
- Vascular Remodeling
- Animals
- Lung
- Endothelium, Vascular
- Pulmonary Artery
- Phenotype