Article

TSC2 is a stress granule suppressor

2026-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Stress granules (SGs) are dynamic, membrane-less ribonucleoprotein assemblies that form through liquid-liquid phase separation to prioritize stress-survival proteostasis. Through reanalysis of a Drosophila genome-wide RNAi screen, we identified a set of conserved SG suppressor genes and validated the top candidate, Tsc2, in both mouse and human cell lines. We illustrate that the complete loss o...

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Literature Corpus work: 967a44ef-e934-521a-8c2a-6bde039e1c80
DOI: 10.64898/2026.05.21.726761

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