Article

mTOR pathway gene knockout results in mTOR-dependent cellular aggregation

2025-11-04

Abstract excerpt

Malformations of cortical development (MCD) caused by variants in mTOR pathway genes (MPGs) are a leading cause of drug-resistant epilepsy. Characteristic histopathological features of MPG-associated MCD include cytomegaly and cortical dyslamination often with neurons in abnormally close apposition (aggregates). We hypothesized that cellular aggregation is an mTOR-dependent phenotype. Tsc2, Nprl3, Stradα , or Kp...

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Literature Corpus work: 2e003c13-c583-52ae-804b-fb915e699611
DOI: 10.1101/2025.11.02.685388

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