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Article

TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation

22 Apr 2021

Abstract excerpt

Abstract Tuberous sclerosis complex (TSC) is caused by mutations of either the TSC1 or TSC2 tumor suppressor gene. TSC causes tumors of the brain, heart, kidney, skin and lymphangioleiomyomatosis (LAM). Here we report that the TSC2 protein physically binds to high-density lipoprotein binding protein (HDLBP), also called vigilin, a core stress granule (SG) protein, and that TSC2 localizes to SGs. SGs contain mRNAs...

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PMID: 33888601
DOI: 10.1158/1541-7786.mcr-20-1046

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