Article

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signalling to pericytes

2018-06-27

Abstract excerpt

Vascular compromise occurs early in Alzheimer’s disease (AD) and other dementias 1–3 . Amyloid β (Aβ) reduces cerebral blood flow 4–6 and, as most of the cerebral vasculature resistance is in capillaries 7 , Aβ might mainly act on contractile pericytes on capillary walls 8–10 . Employing human tissue to establish disease-relevance, and rodent experiments to define mechanism, we now show that Aβ constricts brai...

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Identifiers and source

Literature Corpus work: 962c5938-7193-5733-a275-8e6d89817cb8
DOI: 10.1101/357095

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