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Article

Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004

Myung Kyungjae, Smith Stephanie, Kolodner Richard D

Abstract excerpt

The accumulation of gross chromosomal rearrangements (GCRs) is characteristic of cancer cells. Multiple pathways that prevent GCRs, including S-phase cell cycle checkpoints, homologous recombination, telomere maintenance, suppression of de novo telomere addition, chromatin assembly, and mismatch repair, have been identified in Saccharomyces cerevisiae. However, pathways that promote the formation of GCRs are not...

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Identifiers

PMID: 15514023
DOI: 10.1073/pnas.0407010101
PMCID: PMC528767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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