Article

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors

2023-04-07

Abstract excerpt

Attenuating aberrant transcriptional circuits holds great promise for the treatment of numerous diseases, including cancer. However, development of transcriptional inhibitors is hampered by the lack of a generally accepted functional cellular readout to characterize their target specificity and on-target activity. We benchmarked the direct gene-regulatory signatures of six agents reported as inhibitors of the onco...

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Literature Corpus work: 95f33f18-3deb-5eec-ba04-1029262ca8d2
DOI: 10.1101/2023.04.07.536032

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Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitorsDOI 10.1101/2023.04.07.536032Read

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