Article

Illuminating kinase inhibitors biology by cell signaling profiling

2022-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Protein kinase inhibitors (PKI) are promising drug candidates for many diseases. However, even selective PKIs interact with multiple kinases and non-kinase targets. Existing technologies detect these interactions but not the resultant biological effects. Here, we describe an orthogonal PKI evaluation approach that entails fingerprinting of cell signaling responses. As the readout, we profiled th...

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Literature Corpus work: 6c0fc4e0-1923-52e1-a674-daa81282a336
DOI: 10.1101/2022.04.03.486887

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