Article

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

2026-05-21

Abstract excerpt

In cancer therapy, traditional approaches often overlook the dynamic nature of drug-target interactions. We introduce kinetic fingerprints as a mechanistically informative tool to guide kinase inhibitor design and predict clinical performance. Profiling 172 compounds across multiple KIT conformations, including the oncogenic D816V mutation, show that prolonged residence time determines therapeutic success, while m...

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Identifiers and source

Literature Corpus work: 89672057-13b8-5741-b707-6564b88fc00d
DOI: 10.64898/2026.05.20.726488

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