Article

Hierarchical small molecule inhibition of MYST acetyltransferases

2025-04-27

Abstract excerpt

MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical trials of breast cancer. However, the comparative properties of these small molecules remains to be directly assessed....

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Literature Corpus work: 63c6f892-adc7-55c1-b555-12abbd035cfc
DOI: 10.1101/2025.04.25.650653

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