Article

Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes

2024-05-03

Abstract excerpt

A central challenge in chemical biology is to distinguish molecular families in which small structural changes trigger large changes in cell biology. Such families might be ideal scaffolds for developing cell-selective chemical effectors – for example, molecules that activate DNA damage responses in malignant cells while sparing healthy cells. Across closely related structural variants, subtle structural changes h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10b477c2-29c0-51d2-a31b-7cf5facb6092
DOI: 10.1101/2024.05.01.591362

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single Cell Profiling Distinguishes Leukemia-Selective ChemotypesDOI 10.1101/2024.05.01.591362Read

Drug-perturbation-based stratification of blood cancerSemantic proximity Read

A deep single cell mass cytometry approach to capture canonical and noncanonical cell cycle statesSemantic proximity Read

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoningSemantic proximity Read

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cellsSemantic proximity Read

An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screeningSemantic proximity Read

Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor ScreeningSemantic proximity Read

Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses.Semantic proximity Read

Patient-tailored design of AML cell subpopulation-selective drug combinationsSemantic proximity Read

Large-scale cytological profiling for functional analysis of bioactive compounds.Semantic proximity Read

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin ribosideSemantic proximity Read

Flow Cytometry: Impact on Early Drug Discovery.Semantic proximity Read

Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.Semantic proximity Read