Article

Genomic MET amplification occurs early in NF1-related malignant peripheral nerve sheath tumor (MPNST) progression and is a potent therapeutic target

2017-10-05

Abstract excerpt

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly resistant sarcomas that occur in up to 13% of individuals with Neurofibromatosis Type 1 (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions in NF1 and TP53 , with concomitant amplifications of MET , HGF , and EGFR . To examine the role of MET in MPNST progr...

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Literature Corpus work: 95ebca4b-a329-5489-87a0-9780b757eb18
DOI: 10.1101/199000

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