Article

Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo

2021-07-07

Abstract excerpt

<h4>Background</h4> Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that display complex molecular and genetic alterations. Powerful tumor suppressors CDKN2A and TP53 are commonly disrupted in these lesions along with NF1 , a gene that encodes a negative regulator of Ras. Many additional factors have been implicated in MPNST pathogenesis. A greater understanding of critical drivers of...

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Literature Corpus work: f6a43f8b-b5d7-5787-b4b8-77b4ddec5bc6
DOI: 10.1101/2021.07.07.451475

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