Article

Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTs

2017-10-05

Abstract excerpt

We previously reported that cooperative RAS-MET signaling drives disease progression in NF1-related MPNSTs, and that MET inhibition results in downstream inhibition of RAS/MAPK in the context of MET amplification. This study revealed that response to MET inhibition appeared to be modulated by P53 gene status. It is currently unclear how P53 function affects kinome signaling and response to kinase inhibition. Her...

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Literature Corpus work: 36adf43f-f8d6-57b4-87f3-a07ebff98ea7
DOI: 10.1101/199026

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