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Article

FOXM1, MEK, and CDK4/6: New targets for MPNST therapy

2023-08-02

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) are deadly sarcomas that desperately need effective therapies. Half of all MPNSTs arise in patients with Neurofibromatosis Type I (NF1), a common inherited disease. NF1 patients can develop benign lesions called Plexiform Neurofibromas (PNFs), often in adolescence, and over time some PNFs, but not all, will transform into MPNSTs. A deeper understanding of the molec...

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Literature Corpus work
cb1f38d4-98e5-58e8-99c4-0bca0e8f8e03
DOI
10.20944/preprints202308.0075.v1
Open publication

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FOXM1, MEK, and CDK4/6: New targets for MPNST therapyDOI 10.20944/preprints202308.0075.v1
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