Article

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

2023-01-19

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. TP53 mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms underlying TP53- mediated therapy responses ar...

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Literature Corpus work: 7b67ae22-5332-5787-8750-a7421443f3ec
DOI: 10.1101/2023.01.18.523629

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