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Article

Genomic Profiling in Patients With Malignant Peripheral Nerve Sheath Tumors Reveals Multiple Pathways With Targetable Mutations.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Aug 2018

Kaplan Henry G, Rostad Steven, Ross Jeffrey S, Ali Siraj M, Millis Sherri Z

Abstract excerpt

Background: The aim of this study was to determine the frequency of alterations in BRAF and other RAS/RAF genes, as well as other targetable pathways in malignant peripheral nerve sheath tumors (MPNSTs). Patients and Methods: Pathology specimens were available for 2 cohorts: (1) patients with MPNST at Swedish Cancer Institute (n=17) from 2004 through 2016, and (2) patients with MPNST evaluated for >300 genomic...

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PMID: 30099373
DOI: 10.6004/jnccn.2018.7033

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BRAF

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