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Article

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.

EBioMedicine - 1 Jul 2016

Patel Ami V, Chaney Katherine E, Choi Kwangmin, Largaespada David A, Kumar Ashish R, Ratner Nancy

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue sarcomas that are a major source of mortality in neurofibromatosis type 1 (NF1) patients. To identify MPNST driver genes, we performed a lentiviral short hairpin (sh) RNA screen, targeting all 130 genes up-regulated in neurofibroma and MPNSTs versus normal human nerve Schwann cells. NF1 mutant cells show activation of RAS/MAPK signaling, so a...

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Source

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Identifiers

PMID: 27333032
DOI: 10.1016/j.ebiom.2016.06.007
PMCID: PMC4972548

Genes

MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.PMID 27333032Read ↗

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Molecular targets for NF1-associated malignant peripheral nerve sheath tumorSemantic proximity Read ↗

Large-Scale Molecular Comparison of Human Schwann Cells to Malignant Peripheral Nerve Sheath Tumor Cell Lines and TissuesSemantic proximity Read ↗

Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growthSemantic proximity Read ↗

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