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Article

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

13 Mar 2024

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. TP53 mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms underlying TP53-mediated therapy responses are...

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PMID: 38480916
DOI: 10.1038/s41388-024-03000-9

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