Targeting Foxp3 Tumor Intrinsic Effects Using Adenoviral Vectors in Experimental Breast Cancer

Abstract excerpt

Regulatory T cell master transcription factor, Forkhead box P3 (Foxp3) has been detected in cancer cells, but its role in breast tumor pathogenesis remains controversial. Here we assessed Foxp3 tumor intrinsic effects in experimental breast cancer using a Foxp3 binder peptide (P60) that impairs Foxp3 nuclear translocation. Cisplatin upregulated Foxp3 expression in HER2+ and triple negative breast cancer (TNBC) cel...

Topics

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• Antigen Presentation
• Cyclin-Dependent Kinase Inhibitor p27
• Cytotoxicity, Immunologic
• Forkhead Transcription Factors
• Histocompatibility Antigens Class I
• S-Phase Kinase-Associated Proteins
• T-Lymphocytes, Cytotoxic
• X-Linked Inhibitor of Apoptosis Protein

Identifiers and source

Literature Corpus work

95eb32f1-2e09-5dbb-ac3b-02462772e2a0

DOI

10.20944/preprints202308.0087.v1