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Article

FOXP3 suppresses breast cancer metastasis through downregulation of CD44

14 Feb 2015

Abstract excerpt

Forkhead box protein 3 (FOXP3) plays an important role in breast cancer as an X-linked tumor suppressor gene. However, the biological functions and significance of FOXP3 in breast cancer metastasis remain unclear. Here, we find that, clinically, nuclear FOXP3 expression is inversely correlated with breast cancer metastasis. Moreover, we demonstrate that FOXP3 significantly inhibits adhesion, invasion and...

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PMID: 25683728
DOI: 10.1002/ijc.29482

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