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Article

Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

PloS one - 1 Jan 2013

Nair Smita, Aldrich Amy J, McDonnell Eoin, Cheng Qing, Aggarwal Anshu, Patel Pujan, Williams Monique M, Boczkowski David, Lyerly H Kim, Morse Michael A, Devi Gayathri R

Abstract excerpt

The forkhead transcription factor FOXP3 is necessary for induction of regulatory T lymphocytes (Tregs) and their immunosuppressive function. We have previously demonstrated that targeting Tregs by vaccination of mice with murine FOXP3 mRNA-transfected dendritic cells (DCs) elicits FOXP3-specific T cell responses and enhances tumor immunity. It is clear that FOXP3 expression is not restricted to T-cell lineage and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23341929
DOI: 10.1371/journal.pone.0053150
PMCID: PMC3544902

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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