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Article

The dual role of the X‐linked FoxP3 gene in human cancers

25 Mar 2011

Abstract excerpt

The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the...

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Identifiers

PMID: 21489891
DOI: 10.1016/j.molonc.2011.03.001

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