Article

Age-associated B cells (ABCs) develop from a CNS-localized progenitor pool into a pro-inflammatory phenotype after stroke

2026-03-04

Abstract excerpt

Aging and age-related diseases like ischemic stroke induce chronic lymphocyte recruitment into the central nervous system (CNS). Conflicting effects on post-stroke functional recovery, however, are secondary to the differences in responding lymphocyte populations that shift immunophenotype with both ischemic injury and age. To better define CNS-localized B cell subsets, we used flow cytometry, single-cell RNA sequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95c55275-0ec2-5c20-b888-0a8d093bfde8
DOI: 10.64898/2026.03.02.709112

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Age-associated B cells (ABCs) develop from a CNS-localized progenitor pool into a pro-inflammatory phenotype after strokeDOI 10.64898/2026.03.02.709112Read

Brain endothelial cells are exquisite sensors of age-related circulatory cuesSemantic proximity Read

Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.Semantic proximity Read

Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived modelsSemantic proximity Read

Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotypeSemantic proximity Read

Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescenceSemantic proximity Read

Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrowSemantic proximity Read

Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life.Semantic proximity Read

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity.Semantic proximity Read

The Dynamics of B Cell Aging in Health and DiseaseSemantic proximity Read

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in miceSemantic proximity Read

Lung environment in healthy old age shapes the phenotype and CCR2-mediated recruitment of a subset of apoptotic, high-turnover alveolar macrophagesSemantic proximity Read

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging processSemantic proximity Read