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Article

Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life.

The Journal of experimental medicine - 5 Apr 2021

Kibler Artur, Budeus Bettina, Homp Ekaterina, Bronischewski Kevin, Berg Victoria, Sellmann Ludger, Murke Florian, Heinold Andreas, Heinemann Falko M, Lindemann Monika, Bekeredjian-Ding Isabelle, Horn Peter A, Kirschning Carsten J, Küppers Ralf, Seifert Marc

Abstract excerpt

Human memory B cells (MBCs) are generated and diversified in secondary lymphoid tissues throughout the organism. A paired immunoglobulin (Ig)-gene repertoire analysis of peripheral blood (PB) and splenic MBCs from infant, adult, and elderly humans revealed that throughout life, circulating MBCs are comprehensively archived in the spleen. Archive MBC clones are systematically preserved and uncoupled from...

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Identifiers

PMID: 33538775
DOI: 10.1084/jem.20201952
PMCID: PMC7868796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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