Article

Molecular basis for the activation of the Fatty Acid Kinase complex of <i>Staphylococcus aureus</i>

2024-03-19

Abstract excerpt

Gram-positive bacteria utilize a Fatty Acid Kinase (FAK) complex to harvest fatty acids from the environment. The complex, consisting of the fatty acid kinase, FakA, and an acyl carrier protein, FakB, is known to impact virulence and disease outcomes. However, FAK’s structure and enzymatic mechanism remain poorly understood. Here, we used a combination of modeling, biochemical, and cell-based approaches to establi...

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Literature Corpus work: 95c12cef-c0b8-54be-9f41-d1ef234c76b4
DOI: 10.1101/2024.03.19.585040

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