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Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant <i>Escherichia coli</i> sensitivity to previously ineffective antibiotics

2022-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic resistance is one of the most prominent threats to modern medicine. In the latest World Health Organization list of bacterial pathogens that urgently require new antibiotics, nine out of 12 are Gram-negative, with four being of ‘Critical Priority’. One crucial barrier restricting antibiotic efficacy against Gram-negative bacteria is their unique cell envelope. While fatty acids are a...

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Literature Corpus work
7f58273d-af29-5ef7-93d9-46911a6ce02b
DOI
10.1101/2022.02.18.481121
Open publication

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