Article
The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism.
mBio - 15 Dec 2020
Reithuber Elisabeth, Nannapaneni Priyanka, Rzhepishevska Olena, Lindgren Anders E G, Ilchenko Oleksandr, Normark Staffan, Almqvist Fredrik, Henriques-Normark Birgitta, Mellroth Peter
Abstract excerpt
Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity. We identified the alkylated dicyclohexyl carboxylic acid 2CCA-1 as a potent inducer of...
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