Article

The double-edged role of FASII regulator FabT in <i>Streptococcus pyogenes</i> infection

2023-06-07

Abstract excerpt

In Streptococcus pyogenes , the type II fatty acid (FA) synthesis pathway FASII is feedback- controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Despite FabT defects being linked to reduced virulence in animal models, spontaneous fabT mutants arise in vivo . To resolve this paradox, we characterized the conditions and mechanisms that require FabT activity, and those that promote fabT mutant...

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Literature Corpus work: 590046ad-24e0-5434-a595-534b4ac247f5
DOI: 10.1101/2023.06.07.543851

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