Article

Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells

2023-04-04

Abstract excerpt

Somatic mutations can lead to the transformation of healthy cells into malignant cells and allow their evasion from immune surveillance. To uncover genes that play a role in the detection and lysis of tumor cells by natural killer (NK) cells, a B lymphoblastoid cell line was subjected to a genome-wide CRISPR screen. Among the top hits that facilitated NK evasion was SPPL3 , which encodes an intramembrane protease...

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Literature Corpus work: da70f36d-441e-5cae-8280-4096a5d12044
DOI: 10.1101/2023.04.03.535404

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