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Article

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Scientific reports - 23 Mar 2016

Venkitachalam Srividya, Revoredo Leslie, Varadan Vinay, Fecteau Ryan E, Ravi Lakshmeswari, Lutterbaugh James, Markowitz Sanford D, Willis Joseph E, Gerken Thomas A, Guda Kishore

Abstract excerpt

The molecular basis of aberrant protein glycosylation, a pathological alteration widespread in colorectal cancers (CRC), and the mechanisms by which it contributes to tumor progression remain largely unknown. We performed targeted re-sequencing of 430 glycosylation-associated genes in a series of patient-derived CRC cell lines (N = 31) and matched primary tumor tissues, identifying 12 new significantly mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27004849
DOI: 10.1038/srep23642
PMCID: PMC4804330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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