Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy

Abstract excerpt

Lipid droplets (LDs) play a central role in regulating metabolism in stress-induced conditions, including one triggered by nutrient deprivation. Unravelling the protein networks involved in the biogenesis of LDs and their causative and functional roles in health and disease continue to evolve. To this cause, genetic manipulation of the lipid metabolic network or supplementation of high fat diet/ oleic acid (OA) ar...

Topics

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• Autophagy in Disease and Therapy
• Cholesterol Esters
• Data Mining
• Databases as Topic
• Intracellular Space
• Lipid Droplets
• Lipid metabolism and biosynthesis
• Phenotype

Identifiers and source

Literature Corpus work

6eaede68-38fc-54f5-a469-7abc01dc6725

DOI

10.1101/2025.01.10.632143