Article
Bitter taste receptors influence glucose homeostasis.
PloS one - 1 Jan 2008
Dotson Cedrick D, Zhang Lan, Xu Hong, Shin Yu-Kyong, Vigues Stephan, Ott Sandra H, Elson Amanda E T, Choi Hyun Jin, Shaw Hillary, Egan Josephine M, Mitchell Braxton D, Li Xiaodong, Steinle Nanette I, Munger Steven D
Abstract excerpt
TAS1R- and TAS2R-type taste receptors are expressed in the gustatory system, where they detect sweet- and bitter-tasting stimuli, respectively. These receptors are also expressed in subsets of cells within the mammalian gastrointestinal tract, where they mediate nutrient assimilation and endocrine responses. For example, sweeteners stimulate taste receptors on the surface of gut enteroendocrine L cells to elicit...
Topics
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Enteroendocrine Cells
- Family
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Glucose
- Homeostasis
- Humans