Article

Beyond Co-Existence: Early α-Synuclein-Amyloid-β42 Association from Molecular Dynamics Simulations

2026-02-02

Abstract excerpt

Amyloid-β (Aβ) deposits often appear in Parkinson's disease and α-synuclein (α-syn) pathology in Alzheimer's disease. As soluble oligomers contribute importantly to cytotoxicity, their early crosstalk is critical to understand. Using all-atom molecular dynamics, we investigated how the initial oligomeric configuration of Aβ42 shapes its early association with α-syn, simulating α-syn with (i) one Aβ42 monomer, (ii)...

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Literature Corpus work: 959ba1e6-2ced-59cd-a3d6-23f12ea2e7d1
DOI: 10.64898/2026.01.29.702600

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