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Article

Polymorphic structures of Alzheimer's β-amyloid globulomers.

PloS one - 1 Jan 2011

Yu Xiang, Zheng Jie

Abstract excerpt

BACKGROUND: Misfolding and self-assembly of Amyloid-β (Aβ) peptides into amyloid fibrils is pathologically linked to the development of Alzheimer's disease. Polymorphic Aβ structures derived from monomers to intermediate oligomers, protofilaments, and mature fibrils have been often observed in solution. Some aggregates are on-pathway species to amyloid fibrils, while the others are off-pathway species that do not...

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PMID: 21687730
DOI: 10.1371/journal.pone.0020575
PMCID: PMC3110195

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