Microtubule forces drive nuclear damage in <i>LMNA</i> cardiomyopathy

Abstract excerpt

Nuclear homeostasis requires a balance of forces between the cytoskeleton and nucleus. Mutations in the LMNA gene, which encodes the nuclear envelope proteins lamin A/C, disrupt this balance by weakening the nuclear lamina. This results in nuclear damage in contractile tissues and ultimately muscle disease. Intriguingly, disrupting the LINC complex that connects the cytoskeleton to the nucleus has emerged as a pr...

Topics

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• Cardiomyopathies
• Chromatin
• Disease Models, Animal
• Heart Conduction System
• Lamin Type A
• Mechanotransduction, Cellular
• Mutation
• Nuclear Structure and Function

Identifiers and source

Literature Corpus work

3852c730-2774-5c5c-9bff-6450ebebb677

DOI

10.1101/2024.02.10.579774